School / Department:
Graduate School of Public Health / Human Genetics
An NIH R01-funded postdoctoral position is available in the laboratory of Dr. Beth Roman in the Department of Human Genetics at the University of Pittsburgh. This position provides an outstanding opportunity for cross-disciplinary training, requiring close collaboration with the laboratories of Dr. Lance Davidson (Bioengineering) and Dr. Andrew Hinck (Structural Biology). We are looking for a productive, highly motivated scientist to dissect the interaction between bone morphogenetic protein (BMP)/ALK1 signaling and mechanical force in controlling directed endothelial cell migration, using zebrafish and endothelial cell culture models. Our ultimate goal is to understand how disruption of ALK1 signaling associated with the genetic vascular disorder, hereditary hemorrhagic telangiectasia (HHT), causes arteriovenous malformations (AVMs). AVMs are direct connections between arteries and veins that can lead to hemorrhage and stroke.
The University of Pittsburgh is a collaborative, collegial environment for biomedical research. Our laboratory is part of a large, interactive zebrafish community, and we are affiliated with the Heart, Lung, and Blood Vascular Medicine Institute (VMI), which houses numerous laboratories focused on basic and translational cardiovascular research. Our laboratory is also integral to the UPMC/Pitt HHT enter of Excellence, affording the opportunity to translate research findings to a clinical care setting.
Qualified candidates must have a PhD in biology, biomechanics, or other relevant field, a strong publication record, and excellent oral and written English communication skills. Expertise in biomechanics and endothelial cell culture is preferred. Previous experience with zebrafish, dynamic live-cell imaging, confocal microscopy, and/or image analysis is desired. Interested candidates should send a brief cover letter (maximum 1-page) summarizing scientific accomplishments and outlining motivation for this position; a full CV; and full contact information for three professional references to Dr. Beth Roman at firstname.lastname@example.org