POSTDOCTORAL POSITION available to participate in NIH-funded research project to study the role of mitochondria dysfunction in lung injury, repair and fibrosis. Because aging a major risk factor for IPF, we study the role of mitochondria dysfunction and altered proteostasis in the activation of pro-fibrotic responses in the lung epithelial cell. Our studies have found that mitochondrial quality control plays a critical role in the genesis of aging related susceptibility to lung fibrosis. Our research is aimed to identify novel diagnostic and therapeutic mitochondrial targets to control lung fibrosis. In parallel, our laboratory analyzes the role of mitochondrial homeostasis in the pathogenesis of cardiovascular diseases. The current study will involve state of the art molecular based approaches, mitochondrial function and homeostasis assessment techniques, mouse models of lung injury and fibrosis, novel 3D lung tissue culture assays, and analyses of human samples. The successful applicant will have the opportunity to significantly contribute to the discovery of a novel pathogenic pathway with translational potential in pulmonary fibrosis disease. Our lab is committed to the career development of our lab members. Please send a brief cover letter, CV and the names and phone numbers of 3 references to: Dr. Ana L Mora, Associate Professor, Department of Medicine/Pulmonary Division, Vascular Medicine Institute, University of Pittsburgh School of Medicine, E1246 BST, 200 Lothrop Street Pittsburgh, PA 15206. E-mail: firstname.lastname@example.org
The information for the project involved can be found with the following reference:
Bueno M, Lai Y-C, Romero Y, Brands J, StCroix C, Kamga C, Corey C, Herazo-Maya JD, Sembrant J, Lee J, Duncan SR, Rojas M, Shiva S, Chu CT, Mora AL. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J. Clin Invest.,2015. 125(2):521-38. PMID: 25562319.
The lab is located at the University Of Pittsburgh School Of Medicine. The University of Pittsburgh offers a comprehensive salary program and excellent benefits. The Vascular Medicine Institute and my laboratory are equipped with state-of-the art facilities for mitochondria analyses, molecular biology studies, mouse models of lung fibrosis and PAH, laboratory for hemodynamic studies in murine animal models, and facilities for human lung primary cell culture. Our laboratory and the institute provide a collaborative work environment.
Qualification: Strong written and verbal skills in English are essential. Applicants should have experience in basic cellular and molecular biology. Experience in animal models and/or mitochondria biology is a plus. The position requires a Ph.D. or MD in biomedical bio sciences or related fields and less than two years of postdoctoral experience.